The pursuit of longevity and vitality has fascinated humanity for centuries. In recent years, advancements in science and medicine have given rise to new approaches for slowing or even reversing the aging process. Among the pioneers in this field are individuals who have experimented with a variety of supplements and lifestyle changes to achieve remarkable results. One such person is Dr. John Andrews, a physician who claims to have reversed his biological age by 20 years. In his journey to regain youthful vitality, Dr. Andrews incorporates five key supplements into his daily regimen. This article explores these supplements and how they are believed to contribute to his anti-aging goals.
1. NAD+ Precursors: Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN)
What is NAD+?
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells and plays a crucial role in cellular metabolism, energy production, and DNA repair. As we age, the levels of NAD+ in our cells decline, contributing to reduced mitochondrial function, decreased cellular energy, and an overall acceleration of the aging process.
How Do NR and NMN Work?
Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are precursors to NAD+. When ingested, these molecules are converted into NAD+ in the body, helping to replenish its levels. Studies have shown that supplementing with NR or NMN can:
- Improve mitochondrial function and increase cellular energy.
- Enhance DNA repair mechanisms, which can mitigate age-related cellular damage.
- Boost cognitive function and physical endurance.
- Improve cardiovascular health by promoting the function of blood vessels.
Dr. Andrews' Perspective:
Dr. Andrews credits NAD+ precursors like NR or NMN as foundational to his anti-aging strategy. He takes 250-500 mg of NMN daily, usually in the morning, to maintain higher NAD+ levels throughout the day. According to him, this supplement has significantly boosted his energy levels, improved his sleep quality, and enhanced his overall mental clarity.
2. Resveratrol
What is Resveratrol?
Resveratrol is a polyphenol compound found in red wine, grapes, berries, and peanuts. It is widely known for its antioxidant properties and its ability to activate sirtuins — a group of proteins that play a critical role in cellular health, longevity, and metabolism.
How Does Resveratrol Work?
Resveratrol is believed to mimic the effects of calorie restriction, a proven method to extend lifespan in various organisms. It does so by activating sirtuins, particularly SIRT1, which:
- Enhances mitochondrial function and promotes cellular health.
- Reduces inflammation and oxidative stress.
- Protects against neurodegenerative diseases like Alzheimer's.
- Supports cardiovascular health by improving endothelial function.
Dr. Andrews' Perspective:
Dr. Andrews takes 500 mg of trans-resveratrol daily, ideally with a source of fat (such as yogurt or avocado) to enhance absorption. He believes that resveratrol has been instrumental in maintaining his cardiovascular health and protecting his brain from age-related decline. He also points to studies suggesting that resveratrol works synergistically with NAD+ precursors to optimize cellular health and longevity.
3. Coenzyme Q10 (CoQ10)
What is Coenzyme Q10?
Coenzyme Q10, or CoQ10, is a naturally occurring antioxidant that plays a vital role in cellular energy production. It is found in high concentrations in the heart, liver, kidneys, and pancreas. However, CoQ10 levels decline with age, contributing to a decrease in cellular energy production and an increase in oxidative damage.
How Does CoQ10 Work?
CoQ10 supports the function of mitochondria — the powerhouses of cells — by assisting in the production of adenosine triphosphate (ATP), the primary energy carrier in cells. It also acts as a potent antioxidant, neutralizing free radicals and reducing oxidative stress. Supplementing with CoQ10 can:
- Improve mitochondrial function and energy levels.
- Enhance cardiovascular health by protecting blood vessels and reducing inflammation.
- Reduce muscle pain and weakness, particularly in individuals taking statins.
- Support brain health and protect against neurodegenerative diseases.
Dr. Andrews' Perspective:
Dr. Andrews includes 100-200 mg of ubiquinol, the active form of CoQ10, in his daily supplement routine. He believes that CoQ10 has helped him maintain his energy levels, especially during high-intensity workouts and busy workdays. Furthermore, he suggests that CoQ10 has played a role in supporting his cardiovascular health and reducing age-related oxidative damage.
4. Omega-3 Fatty Acids
What are Omega-3 Fatty Acids?
Omega-3 fatty acids are essential fats that the body cannot produce on its own. They are primarily found in fish (like salmon and mackerel), flaxseeds, chia seeds, and walnuts. The most critical types of omega-3s are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
How Do Omega-3 Fatty Acids Work?
Omega-3s play a crucial role in maintaining cellular membranes, supporting brain function, and reducing inflammation. Regular supplementation with omega-3s has been shown to:
- Lower blood pressure and reduce the risk of heart disease.
- Improve cognitive function and protect against age-related cognitive decline.
- Alleviate symptoms of depression and anxiety.
- Reduce inflammation throughout the body, which is a key factor in aging and many chronic diseases.
Dr. Andrews' Perspective:
Dr. Andrews takes a high-quality omega-3 supplement, aiming for a daily intake of at least 1,000-2,000 mg of combined EPA and DHA. He credits omega-3s with maintaining his heart health, reducing joint inflammation, and promoting cognitive sharpness. He also notes that omega-3s are one of the most well-researched supplements with a wide range of health benefits.
5. Vitamin D3 with K2
What is Vitamin D3 with K2?
Vitamin D3, also known as cholecalciferol, is a fat-soluble vitamin crucial for bone health, immune function, and cellular health. However, recent research suggests that vitamin D3 should be taken with vitamin K2 (menaquinone) to maximize its benefits. Vitamin K2 is essential for directing calcium to the bones and teeth while preventing its deposition in arteries and soft tissues.
How Does Vitamin D3 with K2 Work?
Vitamin D3 enhances calcium absorption in the intestines and promotes bone health. However, without adequate vitamin K2, the absorbed calcium can accumulate in arteries, leading to calcification and cardiovascular problems. Vitamin K2 activates proteins that help direct calcium to the bones and prevent its deposition in the arteries. Together, D3 and K2:
- Strengthen bones and reduce the risk of fractures.
- Boost immune function and protect against infections.
- Promote cardiovascular health by preventing arterial calcification.
- Support muscle function and reduce the risk of falls in older adults.
Dr. Andrews' Perspective:
Dr. Andrews takes 5,000 IU of vitamin D3 with 100 mcg of vitamin K2 daily. He emphasizes that this combination has been crucial for maintaining his bone density and cardiovascular health. He also believes that adequate vitamin D levels are essential for a strong immune system and overall longevity.
While Dr. John Andrews' approach to reversing his biological age by 20 years is not without controversy, his daily supplement regimen reflects some of the most promising research in the field of anti-aging. His combination of NAD+ precursors, resveratrol, CoQ10, omega-3 fatty acids, and vitamin D3 with K2 aims to target multiple pathways of aging, from cellular energy production to inflammation and cardiovascular health.
However, it's essential to remember that supplements are just one piece of the puzzle. A comprehensive anti-aging strategy should also include a healthy diet, regular exercise, sufficient sleep, stress management, and regular medical check-ups. As always, it is advisable to consult with a healthcare professional before starting any new supplement regimen to ensure it is safe and appropriate for individual health needs.
Please note: LA Muscle does not recommend or endorse the above supplements. This article is for information purposes only.
